A platform of diverse human-based hepatic in vitro models & technologies for therapeutic and diagnostic applications
HepaSCREEN takes a tiered approach to the development of a range of industry relevant models and tools for liver toxicity, disease prediction and therapeutic applications. The platform comprises a diverse range of human-based (stem) cell models, ranging from simple (2D, high-throughput compatible…) to more complex hepatic cell systems (3D, co-cultures, fluidic…), tailored to DILI, NAFLD, NASH and diagnostic applications.
HepaSCREEN models
We look for partners who require adaptable in vitro models and tools towards industry needs.
Funding & Projects
iPSCs in DILI & NAFLD
iPSC-based parenchymal and sinusoidal liver cell for DILI and NAFLD studies (iPSC-LiMic)
led by Leo van Grunsven
LIPOSTEM
In vitro model based on human skin-derived stem cells to study de novo lipogenesis in the liver
led by Tamara Vanhaecke
iPSCs & FIBROSIS
A novel pooled functional genomics strategy in inducible pluripotent stem cells for the identification of therapeutic targets for liver fibrosis
led by Leo van Grunsven
TWINALT
Twinning towards excellence in alternative methods for toxicity assessment
led by Tamara Vanhaecke
ChOLLATERAL
Generation of an adverse outcome pathway network on cholestatic liver injury for mechanism-based in vitro testing of chemicals
led by Mathieu Vinken
