A platform of diverse human-based hepatic in vitro models & technologies for therapeutic and diagnostic applications


    HepaSCREEN takes a tiered approach to the development of a range of industry relevant models and tools for liver toxicity, disease prediction and therapeutic applications. The platform comprises a diverse range of human-based (stem) cell models, ranging from simple (2D, high-throughput compatible…) to more complex hepatic cell systems (3D, co-cultures, fluidic…), tailored to DILI, NAFLD, NASH and diagnostic applications.



    HepaSCREEN models


    We look for partners who require adaptable in vitro models and tools towards industry needs. 



    Funding & Projects

    iPSCs in DILI & NAFLD​

    iPSC-based parenchymal and sinusoidal liver cell for DILI and NAFLD studies (iPSC​-LiMic)

    led by Leo van Grunsven

    LIPOSTEM

    In vitro  model based on human skin-derived stem cells to study de novo lipogenesis in the liver

    led by Tamara Vanhaecke

    iPSCs & FIBROSIS​

    A novel pooled functional genomics strategy in inducible pluripotent stem cells for the identification of therapeutic targets for liver fibrosis

    led by Leo van Grunsven

    TWINALT

    Twinning towards excellence in alternative methods for toxicity assessment

    led by Tamara Vanhaecke

    ChOLLATERAL

    Generation of an adverse outcome pathway network on cholestatic liver injury for mechanism-based in vitro testing of chemicals

    led by Mathieu Vinken